Dr. Nora BOURBIA

Group Leader of the Neurobiology and Physiology group at Public Health England, Centre for Radiation, Chemical and Environmental Hazards (PHE CRCE)

Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat.

Behav Brain Res. 2010 May 1;209(1):174-8. doi: 10.1016/j.bbr.2010.01.021.

Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat.

Ansah OB, Bourbia N, Gonçalves L, Almeida A, Pertovaara A.

Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland.

Abstract
The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) followingamygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation ofamygdaloid group I metabotropic GluRs, mGluR(1) and mGluR(5), and the NMDA-R contributes to maintenance of sensory and emotionalcomponents of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.

Link

Leave a Reply

Your email address will not be published. Required fields are marked *.

*
*
You may use these <abbr title="HyperText Markup Language">HTML</abbr> tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>

This site uses Akismet to reduce spam. Learn how your comment data is processed.