Dr. Nora BOURBIA

Group Leader of the Neurobiology and Physiology group at Public Health England, Centre for Radiation, Chemical and Environmental Hazards (PHE CRCE)

Category: Scientific Publications

The guanine nucleotide exchange factor, Spata13, influences social behaviour and nocturnal activity

Scand J Pain. 2018 Jul 1;2(3):137-138. doi: 10.1016/j.sjpain.2011.05.001.  The guanine nucleotide exchange factor, Spata13, influences social behaviour and nocturnal activity Nora Bourbia, Paige Chandler, Gemma Codner, Gareth Banks, and Patrick M. Nolan Spermatogenesis-associated protein 13 (Spata13) is a guanine nucleotide exchange factor (GEF) enriched in discrete brain regions in the adult, with pronounced expression in the […]

Involvement of the periaqueductal gray in the descending antinociceptive effect induced by the central nucleus of amygdala

Physiol Res. 2018 Aug 16;67(4):647-655. Involvement of the periaqueductal gray in the descending antinociceptive effect induced by the central nucleus of amygdala Nora BOURBIA, Antti PERTOVAARA. Abstract Here we studied whether descending control of mechanical nociception by glutamate in the central nucleus of the amygdala (CeA) of healthy control animals is induced by amygdaloid NMDA […]

Bidirectional amygdaloid control of neuropathic hypersensitivity mediated by descending serotonergic pathways acting on spinal 5-HT3 and 5-HT1A receptors

Behav Brain Res. 2014 Dec 31 Bidirectional amygdaloid control of neuropathic hypersensitivity mediated by descending serotonergic pathways acting on spinal 5-HT3 and 5-HT1A receptors Sagalajev B, Bourbia N (shared the first-authorship), Beloushko E, Wei H, Pertovaara A. Abstract Amygdala is involved in processing of primary emotions and particularly its central nucleus (CeA) also in pain […]

Descending effect on spinal nociception by amygdaloid glutamate varies with the submodality of noxious test stimulation

Neurosci Lett. 2014 Jun 6;570:26-31 Descending effect on spinal nociception by amygdaloid glutamate varies with the submodality of noxious test stimulation Nora Bourbia, Boriss Sagalajev, Antti Pertovaara Abstract Amygdala has an important role in the processing of primary emotions, such as fear. Additionally, amygdala is involved in processing and modulation of pain. While the amygdala, […]

Is finding the common biological link(s) between pain and affect an infinity quest?

Scandinavian Journal of Pain July 2011 (Vol. 2, Issue 3, Pages 137-138) Is finding the common biological link(s) between pain and affect an infinity quest? Nora Bourbia, Antti Pertovaara Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland. Abstract Clinical studies have demonstrated comorbidity between pain and depression or anxiety [1], [2]. The prevalence of depression in patients […]

Corticotropin-releasing factor in the rat amygdala differentially influences sensory-discriminative and emotional-like pain response in peripheral neuropathy.

J Pain. 2010 Dec;11(12):1461-71. doi: 10.1016/j.jpain.2010.05.004. Corticotropin-releasing factor in the rat amygdala differentially influences sensory-discriminative and emotional-like pain response in peripheral neuropathy. Bourbia N, Ansah OB, Pertovaara A. Institute of Biomedicine/Physiology, University of Helsinki, Finland. Abstract The central nucleus of the amygdala (CeA) is involved in processing and regulation of pain. We determined whether amygdaloid corticotropin-releasingfactor (CRF) contributes to pain modulation in the neuropathic rat. Emotional aspect of pain was assessed by an aversive place-conditioning test and sensory aspect of pain by determining monofilament-induced […]

Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat.

Behav Brain Res. 2010 May 1;209(1):174-8. doi: 10.1016/j.bbr.2010.01.021. Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat. Ansah OB, Bourbia N, Gonçalves L, Almeida A, Pertovaara A. Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland. Abstract The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) followingamygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results […]